Laboratory of
Primary Immunodeficiency
From "Bedside" to "Bench" and back to "Bedside"
Pediatric Immunology Laboratory
Sheba Medical Center
Tel-Aviv University
Raz Somech Laboratory at a Glance
Here at Somech's Laboratory, we are driven by a single goal - to do our part in improving the life of the patients with Primary Immunodeficiencies. Patients with Primary Immunodeficiecy are born with defects in the immune system due to genetic mutation. It is a rare disease, and most of the patients do not survive their first year if left untreated. Thus we focus on; developing and improving strategies to diagnose the patients as early as possible; understanding the mechanism behind the different diseases and developing strategies for novel therapeutics.
Research
Diagnosing PID
National newborn screening (NBS) program already exist for the most severe type of T cell deficiency. However, there are no national programs to detect B cell deficiency and less severe forms of T and B cell deficiencies as of toray. Since early diagnosis of PIDs are critical for treatment of the disease, we are working to expand upon the current NBS, to increase the number of immunological diseases to be diagnosed early in life.
"Successful clinical and translational research requires that science goes where the patients and diseases are"
Characterization of the adaptive immune repertoire using NGS review MARCH 2024.pdf
News
Characterization of the adaptive immune repertoire using NGS
MARCH 2024
Dr. Tal Beit Halevi wrote a review article summarizing the immune repertoire studies characterizing various Primary Immunodeficiencies that were carried out in our Primary Immunodeficiency Laboratory. The review is writen in Hebrew and it is published in the journal "Harefuah", in the March 2024 edition. Click on the picture above to see the article.
We welcome:
Dr. Ido Someckh,
Ms. Coral Haddad and
Ms. Danielle Raveh
Dr. Ido Someck is a physician scientist.
Ms. Coral Haddad is medical student and Ms. Danielle Raveh is a senior High School student, and both are Arrow Project participants for the year 2023-2024.
Publications
Selected publications
Inadequate Activation of γδT- and B-cells in Patient with Wiskott-Aldrich Syndrome (WAS) Portrayed by TRG and IGH Repertoire Analyses
Palevski D, Simon A, Lev A, Somech S and Lee YN
J Clin Immunol. 2023 Jan.
“The past is in the present,
but the future is still in our hands”
Elie Wiesel - Writer, Nobel Peace Prize Winner
Team
Who We Are
Prof. Raz Somech
MD, PhD
Head of Lab
Contact
Address:
Laboratory Building, 2nd Floor, Rooms 266-268,
Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel
Email:
Phone:
03-530-3477