From "Bedside" to "Bench" and back to "Bedside"
Pediatric Immunology Laboratory
Sheba Medical Center
Raz Somech Laboratory at a Glance
Here at Somech's Laboratory, we are driven by a single goal - to do our part in improving the life of the patients with Primary Immunodeficiencies. Patients with Primary Immunodeficiecy are born with defects in the immune system due to genetic mutation. It is a rare disease, and most of the patients do not survive their first year if left untreated. Thus we focus on; developing and improving strategies to diagnose the patients as early as possible; understanding the mechanism behind the different diseases and developing strategies for novel therapeutics.
National newborn screening (NBS) program already exist for the most severe type of T cell deficiency. However, there are no national programs to detect B cell deficiency and less severe forms of T and B cell deficiencies as of toray. Since early diagnosis of PIDs are critical for treatment of the disease, we are working to expand upon the current NBS, to increase the number of immunological diseases to be diagnosed early in life.
"Successful clinical and translational research requires that science goes where the patients and diseases are"
Lessons Learned from Five Years of Newborn Screening for Severe Combined Immunodeficiency (SCID) in Israel
Lev A, Sharir I, Simon AJ et al.
J Allergy Clin Immunol Pract. 2022 Apr 26.
Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation
Lev A, Simon AJ, Barel O, et al.
Front Immunol. 2019;10:1672. Published 2019 Jul 17.
Characterization of T and B cell repertoire diversity in patients with RAG deficiency
Lee YN, Frugoni F, Dobbs K, et al.
Sci Immunol. 2016;1(6):eaah6109.
Timely and Spatially Regulated Maturation of B and T Cell Repertoire During Human Fetal Development
Rechavi E, Lev A, Lee YN et al.
Sci Transl Med. 2015 Feb 25;7(276):276ra25.
“The past is in the present,
but the future is still in our hands”
Elie Wiesel - Writer, Nobel Peace Prize Winner
Who We Are
Professor Raz Somech
Head of Lab