Immunotherapy & Clinical Trials
Pediatric gene therapy trials: the enrollment roadmap
For families considering a pediatric gene therapy clinical trial, the most difficult part is often not finding a study.
Guide catalog
Primary Immunodeficiencies9
- Congenital neutropenia: G-CSF vs stem cell transplant
- MMR vaccine in DiGeorge syndrome: when is it safe?
- CGD prophylaxis: what to gather before starting therapy
Autoimmune & Inflammatory Diseases9
- JIA uveitis screening: how often does your child need it?
- Pediatric lupus treatment: milestones on the recovery path
- PFAPA treatment pathways: which option fits your child
Immunotherapy & Clinical Trials9
- Expanded access vs clinical trials for pediatric patients
- Pediatric stem cell transplant: pre-admission checklist
- Pediatric biologic therapy: avoiding insurance denial traps
Diagnostics & Screening8
- Genetic testing for childhood immune defects: prep checklist
- SCID screening false positives: avoiding diagnostic panic
- TREC vs KREC: comparing newborn immunodeficiency screens
Vaccines & Preventative Health8
- Post-chemo vaccine catch-up: timing traps to avoid
- Flu shot vs nasal spray for children with asthma
- Is rotavirus vaccine shedding risky for sick siblings?
Most recent
Autoimmune & Inflammatory Diseases
Juvenile arthritis biologics: checklist before starting
The 2025 STOP-JIA trial results confirmed what many of us in pediatric rheumatology had suspected for years: earlier…
Vaccines & Preventative Health
Pneumococcal immunization paths for high-risk kids
A pneumococcal vaccine schedule for an immunocompromised child is defined by two variables: the child’s underlying risk…
Diagnostics & Screening
Prenatal genetic screening: when to test for immune defects
The conversation I keep having with genetics counselors goes something like this: a couple arrives after losing a first…
Immunotherapy & Clinical Trials
IVIG vs SCIG: choosing a pediatric infusion route
Intravenous and subcutaneous immunoglobulin replacement constitute the two established administration routes for…
Autoimmune & Inflammatory Diseases
Food allergy immunotherapy: costly diagnostic traps to avoid
Approximately 50 to 60 percent of positive results on standard skin prick tests (SPT) and serum-specific IgE (sIgE)…
Vaccines & Preventative Health
RSV prevention options for high-risk infants
A single dose of a long-acting monoclonal antibody such as nirsevimab provides passive protection against severe…
Diagnostics & Screening
Whole Exome Sequencing Path for Rare Pediatric Immune Disorders
When a child has recurrent, unusually severe, or difficult-to-explain infections, the clinical challenge is not simply…
Immunotherapy & Clinical Trials
Can kids on immunoglobulin therapy get live vaccines?
The deferral question lands on my desk roughly once a week. A family has a child on monthly IVIG for a primary antibody…
Autoimmune & Inflammatory Diseases
Childhood eczema: biologics versus immunosuppressants
For moderate-to-severe pediatric atopic dermatitis, the treatment distinction is no longer simply topical therapy…
Vaccines & Preventative Health
Combination vaccines vs single shots: the cost of splitting
When parents or clinicians consider separating combination vaccines into individual injections, the discussion often…
Immunotherapy & Clinical Trials
Pediatric CAR-T Cell Therapy Pre-Treatment Checklist
The 2017 FDA approval of tisagenlecleucel for pediatric and young adult relapsed/refractory B-cell ALL was supposed to…
Autoimmune & Inflammatory Diseases
Asthma controller meds in kids: when is it safe to stop?
For a child, stepping down asthma controller medication is usually considered only after at least six months of stable…
Primary Immunodeficiencies
Gene therapy or transplant for Wiskott-Aldrich syndrome
Wiskott–Aldrich syndrome has an estimated incidence of approximately 1 in 250,000 live male births. It is an X-linked…
Vaccines & Preventative Health
Vaccine titer tests for kids: costly timing mistakes
Vaccine titer testing for immunocompromised children can answer an important clinical question: has the child produced…
Diagnostics & Screening
Pediatric flow cytometry: checklist before your child's test
In my experience running pediatric immunology cohorts, the difference between a clean flow cytometry readout and a…
Autoimmune & Inflammatory Diseases
Juvenile arthritis therapies: mapping the options
The 2026 American College of Rheumatology guidelines materially change several juvenile idiopathic arthritis treatment…
Diagnostics & Screening
Genetic Panels for Immunodeficiency: Costly Testing Traps
Genetic testing can clarify a child’s immune disorder, change the management pathway, and sometimes prevent years of…
Immunotherapy & Clinical Trials
Parent Checklist for Pediatric Clinical Trial Enrollment
In July 2026, the BMJ published the SPIRIT-C 2026 and CONSORT-C 2026 extensions — a set of new reporting expectations…
Primary Immunodeficiencies
Abnormal SCID Screen: A Parent's Diagnostic Roadmap
An abnormal SCID newborn screen is an urgent finding, but it is not the same as a diagnosis of severe combined…
Autoimmune & Inflammatory Diseases
Allergy immunotherapy for kids: shots, drops, or tablets?
For children with persistent allergic rhinitis, antihistamines and nasal sprays can control symptoms, but they do not…
Vaccines & Preventative Health
Cocooning vs Delayed Vaccines: Two Immunoprotection Routes
A 76.9% reduction in severe acute respiratory infection (SARI) among infants was reported in one study when household…