top of page

Laboratory of
Primary Immunodeficiency

From "Bedside" to "Bench" and back to "Bedside"

Pediatric Immunology Laboratory
Sheba Medical Center
Tel-Aviv University

Raz Somech Laboratory at a Glance

Here at Somech's Laboratory, we are driven by a single goal - to do our part in improving the life of the patients with Primary Immunodeficiencies. Patients with Primary Immunodeficiecy are born with defects in the immune system due to genetic mutation. It is a rare disease, and most of the patients do not survive their first year if left untreated. Thus we focus on; developing and improving strategies to diagnose the patients as early as possible; understanding the mechanism behind the different diseases and developing strategies for novel therapeutics.

Petri Dish


Newborn Baby Foot

Diagnosing PID

National newborn screening (NBS) program already exist for the most severe type of T cell deficiency. However, there are no national programs to detect B cell deficiency and less severe forms of T and B cell deficiencies as of toray. Since early diagnosis of PIDs are critical for treatment of the disease, we are working to expand upon the current NBS, to increase the number of immunological diseases to be diagnosed early in life.

"Successful clinical and translational research requires that science goes where the patients and diseases are"


Yellow paper made ribbon on light blue background_edited.jpg

In commemoration of Rare Disease Day on February 28th, we are excited to share that our international research team is the recipient of the prestigious global Jeffrey Modell Foundation Translational Research Program Award (Cycle 10). The study entitled, “From clinical and molecular characterization to CRISPR genome-editing therapy of RAG1 combined immunodeficiency”,  is a close collaboration between the teams of Dr. Ayal Hendel at Bar-Ilan University and Dr. Raz Somech at Edmond and Lily Safra Children’s Hospital in Israel, and Dr. Jolan Walter University of South Florida at Johns Hopkins All Children’s Hospital and Dr. Kevin Strauss at Clinic for Special Children in the United States. This study could not be possible without many clinicians and scientists working together around the globe. We thank the families, our research and clinical team members, and the Jeffrey Modell Foundation.

Febuary 28, 2023

Kadar Prize Award 2.jpg

Prof. Raz Somech is
2021 Laureate of the
Kadar Prize for Excellence in Research

October 14, 2021


Selected publications

SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma

Lev A, Asleh M, Levy S et al

J Clin Immunol. 2023 Apr

Inadequate Activation of γδT- and B-cells in Patient with Wiskott-Aldrich Syndrome (WAS) Portrayed by TRG and IGH Repertoire Analyses

Palevski D, Simon ALev A, Somech S and Lee YN

J Clin Immunol​. 2023 Jan.

Lessons Learned from Five Years of Newborn Screening for Severe Combined Immunodeficiency (SCID) in Israel

Lev A, Sharir I, Simon AJ et al.

J Allergy Clin Immunol Pract. 2022 Apr 26. 

Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects

Lev A, Lee YN, Sun G et al

J Exp Med. 2021; 218 (3).

Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation

Lev A, Simon AJ, Barel O, et al.  

Front Immunol. 2019;10:1672. Published 2019 Jul 17.

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B

Somech R, Lev A, Lee YN, et al.  

J Immunol. 2017;199(12):4036‐4045.

Characterization of T and B cell repertoire diversity in patients with RAG deficiency

Lee YN, Frugoni F, Dobbs K, et al. 

Sci Immunol. 2016;1(6):eaah6109.

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects

Simon AJ, Lev A, Zhang Y, et al.  

J Exp Med. 2016;213(8):1429‐1440.

Timely and Spatially Regulated Maturation of B and T Cell Repertoire During Human Fetal Development

Rechavi E, Lev A, Lee YN et al. 

Sci Transl Med. 2015 Feb 25;7(276):276ra25.

A Congenital Neutrophil Defect Syndrome Associated With Mutations in VPS45

Vilboux T, Lev A, Malicdan MC, Simon AJ et al. 

N Engl J Med. 2013 Jul 4;369(1):54-65.

“The past is in the present,
but the future is still in our hands”

Elie Wiesel - Writer, Nobel Peace Prize Winner


Who We Are


Prof. Raz Somech


Head of Lab



Thanks for submitting!


Laboratory Building, 2nd Floor, Rooms 266-268,
Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel




bottom of page